Single-cell RNA sequencing of Tocilizumab-treated peripheral blood mononuclear cells

microbiologica

The RNase J-Based mostly RNA Degradosome Is Compartmentalized within the Gastric Pathogen Helicobacter pylori

Posttranscriptional regulation is a serious degree of gene expression management in any cell. In micro organism, multiprotein machines known as RNA degradosomes are central for RNA processing and degradation, and a few had been reported to be compartmentalized inside these organelleless cells. The minimal RNA degradosome of the essential gastric pathogen Helicobacter pylori consists of the important ribonuclease RNase J and RhpA, its sole DEAD field RNA helicase, and performs a serious position within the regulation of mRNA decay and adaptation to gastric colonization.

Right here, the subcellular localization of the H. pylori RNA degradosome was investigated utilizing mobile fractionation and each confocal and superresolution microscopy. 

We established that RNase J and RhpA are peripheral internal membrane proteins and that this affiliation was mediated neither by ribosomes nor by RNA nor by the RNase Y membrane protein. In dwell H. pylori cells, we noticed that fluorescent RNase J and RhpA protein fusions assemble into nonpolar foci. We recognized components that regulate the formation of those foci with out affecting the degradosome membrane affiliation.  

Flotillin, a bacterial membrane scaffolding protein, and free RNA promote focus formation in H. pylori Lastly, RNase J-GFP (RNase J-green fluorescent protein) molecules and foci in cells had been quantified by three-dimensional (3D) single-molecule fluorescence localization microscopy. 

The quantity and dimension of the RNase J foci had been discovered to be scaled with progress section and cell quantity as beforehand reported for eukaryotic ribonucleoprotein granules. In conclusion, we suggest that membrane compartmentalization and the regulated clustering of RNase J-based degradosome hubs symbolize essential ranges of management of their exercise and specificity.

 IMPORTANCE Helicobacter pylori is a bacterial pathogen that chronically colonizes the abdomen of half of the human inhabitants worldwide. An infection by H. pylori can result in the event of gastric pathologies akin to ulcers and adenocarcinoma, which causes as much as 800,000 deaths on this planet every year.

 Persistent colonization by H. pylori depends on regulation of the expression of adaptation-related genes. One main degree of such management is posttranscriptional regulation, which, in H. pylori, largely depends on a multiprotein molecular machine, an RNA degradosome, that we beforehand found. On this research, we established that the 2 protein companions of this machine are related to the membrane of H. pylori Utilizing cutting-edge microscopy, we confirmed that these complexes assemble into hubs whose formation is regulated by free RNA and scaled with bacterial dimension and progress section. Organelleless mobile compartmentalization of molecular machines into hubs emerges as an essential regulatory degree in micro organism.  

microbiologica
microbiologica

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1-CSB-PA030033
  • EUR 266.40
  • EUR 234.00
  • 100ug
  • 50ug
Description: A polyclonal antibody against PEG3. Recognizes PEG3 from Human. This antibody is Unconjugated. Tested in the following application: WB, ELISA;WB:1/500-1/2000.ELISA:1/10000

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CSB-PA022042- each
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Description: A polyclonal antibody against PEG3. Recognizes PEG3 from Human. This antibody is Unconjugated. Tested in the following application: ELISA, WB;WB:1:500-1:3000

PEG3 Antibody

CSB-PA022042-100ul 100ul
EUR 379.2
Description: A polyclonal antibody against PEG3. Recognizes PEG3 from Human. This antibody is Unconjugated. Tested in the following application: ELISA, WB;WB:1:500-1:3000

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EUR 280
Description: Human,Mouse,Rat

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Description: Human,Mouse,Rat

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Description: Available in various conjugation types.

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Description: Available in various conjugation types.

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Description: Available in various conjugation types.

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Description: Available in various conjugation types.

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Description: A polyclonal antibody for detection of PEG3 from Human. This PEG3 antibody is for WB, ELISA. It is affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogenand is unconjugated. The antibody is produced in rabbit by using as an immunogen synthesized peptide derived from the Internal region of human PEG3 at AA range: 1010-1090

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Description: A polyclonal antibody for detection of PEG3 from Human. This PEG3 antibody is for WB, ELISA. It is affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogenand is unconjugated. The antibody is produced in rabbit by using as an immunogen synthesized peptide derived from the Internal region of human PEG3 at AA range: 1010-1090

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Description: A polyclonal antibody for detection of PEG3 from Human. This PEG3 antibody is for WB, ELISA. It is affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogenand is unconjugated. The antibody is produced in rabbit by using as an immunogen synthesized peptide derived from the Internal region of human PEG3 at AA range: 1010-1090

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Description: A Rabbit Polyclonal antibody against PEG3 from Human. This antibody is tested and validated for WB, ELISA, WB, ELISA

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Description: A Rabbit Polyclonal antibody against PEG3 from Human. This antibody is tested and validated for WB, ELISA, WB, ELISA

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Description: Available in various conjugation types.

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Description: Available in various conjugation types.

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  • 100 ug
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  • EUR 878.40
  • 15 nmol
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  • 15 nmol
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Description: N-(Amino-PEG3)-N-bis(PEG3-acid)

N-(Azido-PEG3)-N-bis(PEG3-acid)

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Description: N-(Azido-PEG3)-N-bis(PEG3-acid)

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Description: N-(Azido-PEG3)-N-bis(PEG3-acid)

N-(acid-PEG3)-N-bis(PEG3-amine)

571888 50.0mg
EUR 440

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572821 100.0mg
EUR 500

N-(Azido-PEG3)-N-(PEG2-NH-Boc)-PEG3-acid

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Description: N-(Azido-PEG3)-N-(PEG2-NH-Boc)-PEG3-acid

PEG3 Rabbit pAb

A12671-100ul 100 ul
EUR 369.6

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A12671-200ul 200 ul
EUR 550.8

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EUR 219.6

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EUR 267.6

PEG3-C4-OBn

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Description: PEG3-C4-OBn

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Description: PEG3-C4-OBn

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Description: PEG3-C4-OBn

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Description: PEG3-C4-OBn

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Description: PEG3-C4-OBn

PEG3-(CH2CO2H)2

572082 500.0mg
EUR 610

Biotin PEG3 amine

3024-25mg 25 mg
EUR 222
Description: Biotin PEG3 amine is a carbonyl-reactive biotin derivative that contains a long arm to increase its avidin-binding affinity.

PEG3-O-CH2COOH

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Description: PEG3-O-CH2COOH

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Description: PEG3-O-CH2COOH

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Description: PEG3-O-CH2COOH

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N-(Azido-PEG3)-N-bis(PEG3-NHS ester)

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Description: N-(Azido-PEG3)-N-bis(PEG3-NHS ester)

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Description: N-(Azido-PEG3)-N-bis(PEG3-NHS ester)

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Description: N-(Azido-PEG3)-N-bis(PEG3-NHS ester)

PEG3 Blocking Peptide

AF9152-BP 1mg
EUR 234

PEG3 (untagged)-Human paternally expressed 3 (PEG3), transcript variant 1

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BCN-​exo-​PEG3-​NH2

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Description: BCN-​exo-​PEG3-​NH2

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Description: BCN-​exo-​PEG3-​NH2

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Description: BCN-​exo-​PEG3-​NH2

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Description: BCN-​exo-​PEG3-​NH2

BCN-​exo-​PEG3-​NH2

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Description: BCN-​exo-​PEG3-​NH2

NH-bis(PEG3-OH)

572523 250.0mg
EUR 510

NH-bis(PEG3-Boc)

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Description: NH-bis(PEG3-Boc)

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Description: NH-bis(PEG3-Boc)

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Description: NH-bis(PEG3-Boc)

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Description: NH-bis(PEG3-Boc)

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Description: NH-bis(PEG3-Boc)

NH-bis(PEG3-Boc)

571903 100.0mg
EUR 460

NH-bis(PEG3-acid)

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Description: NH-bis(PEG3-acid)

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Description: NH-bis(PEG3-acid)

NH-bis(PEG3-acid)

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Description: NH-bis(PEG3-acid)

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Description: NH-bis(PEG3-acid)

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Description: NH-bis(PEG3-acid)

NH-bis(PEG3-azide)

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Description: NH-bis(PEG3-azide)

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Description: NH-bis(PEG3-azide)

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Description: NH-bis(PEG3-azide)

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Description: NH-bis(PEG3-azide)

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Description: NH-bis(PEG3-azide)

NH-bis(PEG3-azide)

572816 100.0mg
EUR 760

PEG3-tetrazine, 1 g

1978-1g 1 g
EUR 793.2

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1978-250mg 250 mg
EUR 366

PEG3 (GFP-tagged) - Human paternally expressed 3 (PEG3), transcript variant 1

RG215328 10 µg Ask for price

PEG3 (GFP-tagged) - Human paternally expressed 3 (PEG3), transcript variant 2

RG228688 10 µg Ask for price

PEG3 (GFP-tagged) - Human paternally expressed 3 (PEG3), transcript variant 4

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RG229077 10 µg Ask for price

PEG3 (GFP-tagged) - Human paternally expressed 3 (PEG3), transcript variant 5

RG229078 10 µg Ask for price

Human PEG3 shRNA Plasmid

20-abx953456
  • EUR 961.20
  • EUR 1345.20
  • 150 µg
  • 300 µg

Single-cell RNA sequencing of Tocilizumab-treated peripheral blood mononuclear cells as an in vitro mannequin of irritation

COVID-19 has posed a major risk to international well being. Early knowledge has revealed that IL-6, a key regulatory cytokine, performs an essential position within the cytokine storm of COVID-19. A number of trials are due to this fact wanting on the results of Tocilizumab, an IL-6 receptor antibody that inhibits IL-6 exercise, on remedy of COVID-19, with promising findings. 

As a part of a scientific trial wanting on the results of Tocilizumab remedy on kidney transplant recipients with subclinical rejection, we carried out single-cell RNA sequencing of evaluating stimulated PBMCs earlier than and after Tocilizumab remedy. We leveraged this knowledge to create an in vitro cytokine storm mannequin, to higher perceive the consequences of Tocilizumab within the presence of irritation. Tocilizumab-treated cells had lowered expression of inflammatory-mediated genes and biologic pathways, notably amongst monocytes. These outcomes help the speculation that Tocilizumab might hinder the cytokine storm of COVID-19, by way of an indication of biologic influence on the single-cell degree.   

Useful Characterization of a Putative RNA Demethylase ALKBH6 in Arabidopsis Development and Abiotic Stress Responses

RNA methylation and demethylation, which is mediated by RNA methyltransferases (known as “writers”) and demethylases (known as “erasers”), respectively, are rising as a key regulatory course of in plant growth and stress responses. Though a number of research have proven that AlkB homolog (ALKBH) proteins are potential RNA demethylases, the operate of most ALKBHs is but to be decided. 

 The Arabidopsis thaliana genome accommodates 13 genes encoding ALKBH proteins, the capabilities of that are largely unknown. On this research, we characterised the operate of a possible eraser protein, ALKBH6 (At4g20350), throughout seed germination and seedling progress in Arabidopsis below abiotic stresses. The seeds of T-DNA insertion alkbh6 knockdown mutants germinated quicker than the wild-type seeds below chilly, salt, or abscisic acid (ABA) remedy situations however not below dehydration stress situations. 

Though no variations in seedling and root progress had been noticed between the alkbh6 mutant and wild-type below regular situations, the alkbh6 mutant confirmed a a lot decrease survival fee than the wild-type below salt, drought, or warmth stress. Cotyledon greening of the alkbh6 mutants was a lot greater than that of the wild-type upon ABA utility.  Furthermore, the transcript ranges of ABA signaling-related genes, together with ABI3 and ABI4, had been down-regulated within the alkbh6 mutant in comparison with wild-type vegetation. Importantly, the ALKBH6 protein had a capability to bind to each m6A-labeled and m5C-labeled RNAs. Collectively, these outcomes point out that the potential eraser ALKBH6 performs essential roles in seed germination, seedling progress, and survival of Arabidopsis below abiotic stresses.  

GNAS antibody

70R-21619 50 ul
EUR 522
Description: Rabbit polyclonal GNAS antibody

GNAS antibody

70R-5756 50 ug
EUR 560.4
Description: Rabbit polyclonal GNAS antibody raised against the N terminal of GNAS

GNAS Antibody

32899-100ul 100ul
EUR 302.4

GNAS Antibody

ABD7068 100 ug
EUR 525.6

GNAS Antibody

ABD7388 100 ug
EUR 525.6

GNAS Antibody

1-CSB-PA009596GA01HU
  • EUR 716.40
  • EUR 399.60
  • 150ul
  • 50ul
Description: A polyclonal antibody against GNAS. Recognizes GNAS from Human, Mouse, Rat. This antibody is Unconjugated. Tested in the following application: ELISA, WB

GNAS Antibody

1-CSB-PA147947
  • EUR 380.40
  • EUR 292.80
  • 100ul
  • 50ul
Description: A polyclonal antibody against GNAS. Recognizes GNAS from Human, Mouse, Rat. This antibody is Unconjugated. Tested in the following application: ELISA, WB, IHC;ELISA:1:1000-1:2000, WB:1:200-1:1000, IHC:1:25-1:100

GNAS Antibody

1-CSB-PA247539
  • EUR 380.40
  • EUR 292.80
  • 100ul
  • 50ul
Description: A polyclonal antibody against GNAS. Recognizes GNAS from Human, Mouse, Rat. This antibody is Unconjugated. Tested in the following application: ELISA, WB, IHC;ELISA:1:1000-1:5000, WB:1:200-1:1000, IHC:1:25-1:100

GNAS Antibody

1-CSB-PA307619LA01HU
  • EUR 380.40
  • EUR 402.00
  • 100ug
  • 50ug
Description: A polyclonal antibody against GNAS. Recognizes GNAS from Human. This antibody is Unconjugated. Tested in the following application: ELISA, WB, IHC, IF; Recommended dilution: WB:1:500-1:5000, IHC:1:500-1:1000, IF:1:200-1:500

GNAS Antibody

1-CSB-PA352389LA01HU
  • EUR 380.40
  • EUR 402.00
  • 100ug
  • 50ug
Description: A polyclonal antibody against GNAS. Recognizes GNAS from Human, Mouse, Rat. This antibody is Unconjugated. Tested in the following application: ELISA, WB, IHC, IF; Recommended dilution: WB:1:500-1:5000, IHC:1:20-1:200, IF:1:50-1:200

GNAS Antibody

F40026-0.4ML 0.4 ml
EUR 322.15
Description: Guanine nucleotide-binding proteins (G proteins) are involved as modulators or transducers in various transmembrane signaling systems. The Gs protein is involved in hormonal regulation of adenylate cyclase: it activates the cyclase in response to beta-adrenergic stimuli. Alternative splicing of downstream exons of the GNAS gene is observed, which results in different forms of the stimulatory G protein alpha subunit, a key element of the classical signal transduction pathway linking receptor-ligand interactions with the activation of adenylyl cyclase and a variety of cellular reponses. Multiple transcript variants have been found for this gene, but the full-length nature and/or biological validity of some variants have not been determined. Mutations in this gene result in pseudohypoparathyroidism type 1a, pseudohypoparathyroidism type 1b, Albright hereditary osteodystrophy, pseudopseudohypoparathyroidism, McCune-Albright syndrome, progressive osseus heteroplasia, polyostotic fibrous dysplasia of bone, and some pituitary tumors.

GNAS Antibody

R35181-100UG 100 ug
EUR 339.15
Description: Additional name(s) for this target protein: Guanine nucleotide binding protein alpha stimulating activity polypeptide 1

GNAS Antibody

DF7068 100ul
EUR 280
Description: Human,Mouse,Rat

GNAS Antibody

DF7388 100ul
EUR 280
Description: Human,Mouse,Rat

GNAS Antibody

CAC10438-100ug 100ug
EUR 314

GNAS Antibody

CAC10438-50ug 50ug
EUR 199.2

GNAS Antibody

CAC11323-100ug 100ug
EUR 314

GNAS Antibody

CAC11323-50ug 50ug
EUR 199.2

GNAS Antibody

E10-30780 100ul
EUR 225
Description: Available in various conjugation types.

GNAS Antibody

E10-30780T 100ul
EUR 225
Description: Available in various conjugation types.

GNAS Antibody

E10-30781 100ul
EUR 225
Description: Available in various conjugation types.

GNAS Antibody

E10-30781T 100ul
EUR 225
Description: Available in various conjugation types.

GNAS Antibody

E19-7068 100μg/100μl
EUR 225
Description: Available in various conjugation types.

GNAS Antibody

E19-7388 100μg/100μl
EUR 225
Description: Available in various conjugation types.

GNAS Antibody

E95546 100μg
EUR 255
Description: Available in various conjugation types.

GNAS Antibody

E91416 100μg
EUR 255
Description: Available in various conjugation types.

GNAS Antibody

E92732 100ul
EUR 255
Description: Available in various conjugation types.

GNAS Antibody

DF7068-100ul 100ul
EUR 280

GNAS Antibody

DF7068-200ul 200ul
EUR 350

GNAS Antibody

DF7388-100ul 100ul
EUR 280

GNAS Antibody

DF7388-200ul 200ul
EUR 350

GNAS Complex Locus (GNAS) Antibody (HRP)

20-abx337231
  • EUR 493.20
  • EUR 2214.00
  • EUR 718.80
  • EUR 218.40
  • EUR 360.00
  • 100 ug
  • 1 mg
  • 200 ug
  • 20 ug
  • 50 ug

GNAS Complex Locus (GNAS) Antibody (FITC)

20-abx337232
  • EUR 493.20
  • EUR 2214.00
  • EUR 718.80
  • EUR 218.40
  • EUR 360.00
  • 100 ug
  • 1 mg
  • 200 ug
  • 20 ug
  • 50 ug

GNAS Complex Locus (GNAS) Antibody (Biotin)

20-abx337233
  • EUR 493.20
  • EUR 2214.00
  • EUR 718.80
  • EUR 218.40
  • EUR 360.00
  • 100 ug
  • 1 mg
  • 200 ug
  • 20 ug
  • 50 ug

anti- GNAS antibody

FNab03536 100µg
EUR 606.3
Description: Antibody raised against GNAS

GNAS Antibody (HRP)

20-abx306647
  • EUR 493.20
  • EUR 2214.00
  • EUR 718.80
  • EUR 218.40
  • EUR 360.00
  • 100 ug
  • 1 mg
  • 200 ug
  • 20 ug
  • 50 ug

GNAS Antibody (FITC)

20-abx306648
  • EUR 493.20
  • EUR 2214.00
  • EUR 718.80
  • EUR 218.40
  • EUR 360.00
  • 100 ug
  • 1 mg
  • 200 ug
  • 20 ug
  • 50 ug

NESP55,GNAS Antibody

abx235663-100ug 100 ug
EUR 577.2

GNAS Antibody (Biotin)

20-abx306649
  • EUR 493.20
  • EUR 2214.00
  • EUR 718.80
  • EUR 218.40
  • EUR 360.00
  • 100 ug
  • 1 mg
  • 200 ug
  • 20 ug
  • 50 ug

GNAS complex locus (GNAS) polyclonal antibody

ABP-PAB-11314 100 ug Ask for price

anti- NESP55,GNAS antibody

FNab05663 100µg
EUR 606.3
Description: Antibody raised against NESP55,GNAS

GNAS Antibody, HRP conjugated

1-CSB-PA307619LB01HU
  • EUR 380.40
  • EUR 402.00
  • 100ug
  • 50ug
Description: A polyclonal antibody against GNAS. Recognizes GNAS from Human. This antibody is HRP conjugated. Tested in the following application: ELISA

GNAS Antibody, HRP conjugated

1-CSB-PA352389LB01HU
  • EUR 380.40
  • EUR 402.00
  • 100ug
  • 50ug
Description: A polyclonal antibody against GNAS. Recognizes GNAS from Human. This antibody is HRP conjugated. Tested in the following application: ELISA

GNAS Antibody, FITC conjugated

1-CSB-PA307619LC01HU
  • EUR 380.40
  • EUR 402.00
  • 100ug
  • 50ug
Description: A polyclonal antibody against GNAS. Recognizes GNAS from Human. This antibody is FITC conjugated. Tested in the following application: ELISA

GNAS Antibody, FITC conjugated

1-CSB-PA352389LC01HU
  • EUR 380.40
  • EUR 402.00
  • 100ug
  • 50ug
Description: A polyclonal antibody against GNAS. Recognizes GNAS from Human. This antibody is FITC conjugated. Tested in the following application: ELISA

OAAN01353-50UL - GNAS Antibody

OAAN01353-50UL 50ul
EUR 149

Polyclonal GNAS Antibody (Center)

APR05815G 0.1ml
EUR 580.8
Description: A polyclonal antibody raised in Rabbit that recognizes and binds to Human GNAS (Center). This antibody is tested and proven to work in the following applications:

GNAS Antibody, Biotin conjugated

1-CSB-PA307619LD01HU
  • EUR 380.40
  • EUR 402.00
  • 100ug
  • 50ug
Description: A polyclonal antibody against GNAS. Recognizes GNAS from Human. This antibody is Biotin conjugated. Tested in the following application: ELISA

GNAS Antibody, Biotin conjugated

1-CSB-PA352389LD01HU
  • EUR 380.40
  • EUR 402.00
  • 100ug
  • 50ug
Description: A polyclonal antibody against GNAS. Recognizes GNAS from Human. This antibody is Biotin conjugated. Tested in the following application: ELISA

OAGA00440-100UL - GNAS antibody

OAGA00440-100UL 100ul
EUR 369

OAGA00997-100UL - GNAS antibody

OAGA00997-100UL 100ul
EUR 369

OAAJ07854-100UL - GNAS Antibody

OAAJ07854-100UL 100uL
EUR 319

OAAN01353-100UL - GNAS Antibody

OAAN01353-100UL 100ul
EUR 249

OAAN01353-200UL - GNAS Antibody

OAAN01353-200UL 200ul
EUR 389

Rabbit Polyclonal antibody to GNAS (GNAS complex locus)

TA308888 100 µl Ask for price

Rabbit Polyclonal antibody to GNAS (GNAS complex locus)

TA308889 100 µl Ask for price

GNAS Conjugated Antibody

C32899 100ul
EUR 476.4

GNAS Polyclonal Antibody

A68803
  • EUR 754.26
  • Ask for price
  • Ask for price
  • EUR 470.80
  • 100 ?g
  • 20 ul
  • 50 ul
  • 100 ul

GNAS Polyclonal Antibody

A64422
  • EUR 684.66
  • EUR 117.70
  • EUR 302.50
  • EUR 423.50
  • 100 µg
  • 20 ul
  • 50 ul
  • 100 ul

Polyclonal GNAS Antibody (C-term)

APR04328G 0.1ml
EUR 580.8
Description: A polyclonal antibody raised in Rabbit that recognizes and binds to Human GNAS (C-term). This antibody is tested and proven to work in the following applications:

Polyclonal GNAS Antibody (N-Term)

AMM04827G 0.1ml
EUR 580.8
Description: A polyclonal antibody raised in Rabbit that recognizes and binds to Human GNAS (N-Term). This antibody is tested and proven to work in the following applications:

Monoclonal GNAS Antibody, Clone: 7G6G5

AMM03034G 0.1ml
EUR 633.6
Description: A Monoclonal antibody against Human GNAS. The antibodies are raised in Mouse and are from clone 7G6G5. This antibody is applicable in WB and IHC, FC, ICC, E

Monoclonal GNAS Antibody, Clone: 2A2B7

AMM03035G 0.1ml
EUR 633.6
Description: A Monoclonal antibody against Human GNAS. The antibodies are raised in Mouse and are from clone 2A2B7. This antibody is applicable in WB and IHC, FC, ICC, E

Polyclonal GNAS Antibody (aa385-394)

APR02185G 0.05mg
EUR 580.8
Description: A polyclonal antibody raised in Rabbit that recognizes and binds to Human GNAS (aa385-394). This antibody is tested and proven to work in the following applications:

Polyclonal GNAS Antibody (internal region)

APG00677G 0.1mg
EUR 580.8
Description: A polyclonal antibody raised in Goat that recognizes and binds to Human GNAS (internal region). This antibody is tested and proven to work in the following applications:

GNAS Antibody (G protein alpha S)

F40026-0.08ML 0.08 ml
EUR 140.25
Description: Guanine nucleotide-binding proteins (G proteins) are involved as modulators or transducers in various transmembrane signaling systems. The Gs protein is involved in hormonal regulation of adenylate cyclase: it activates the cyclase in response to beta-adrenergic stimuli. Alternative splicing of downstream exons of the GNAS gene is observed, which results in different forms of the stimulatory G protein alpha subunit, a key element of the classical signal transduction pathway linking receptor-ligand interactions with the activation of adenylyl cyclase and a variety of cellular reponses. Multiple transcript variants have been found for this gene, but the full-length nature and/or biological validity of some variants have not been determined. Mutations in this gene result in pseudohypoparathyroidism type 1a, pseudohypoparathyroidism type 1b, Albright hereditary osteodystrophy, pseudopseudohypoparathyroidism, McCune-Albright syndrome, progressive osseus heteroplasia, polyostotic fibrous dysplasia of bone, and some pituitary tumors.

ARP89242_P050 - Gnas Antibody-N-terminal region

ARP89242_P050 100ul
EUR 389

OABF01371-100UL - GNAS Antibody (OABF01371-100UL)

OABF01371-100UL 100ul
EUR 409

OAAB09358-400UL - GNAS Antibody - C-terminal region

OAAB09358-400UL 400ul
EUR 389

ARP41764_T100-25UL - GNAS Antibody - N-terminal region

ARP41764_T100-25UL 25ul
EUR 99

ARP41765_T100-25UL - GNAS Antibody - C-terminal region

ARP41765_T100-25UL 25ul
EUR 99

ARP42693_P050-25UL - GNAS Antibody - N-terminal region

ARP42693_P050-25UL 25ul
EUR 99

ARP42694_T100-25UL - GNAS Antibody - N-terminal region

ARP42694_T100-25UL 25ul
EUR 99

ARP89242_P050-25UL - GNAS Antibody - N-terminal region

ARP89242_P050-25UL 25ul
EUR 99

GNAS Polyclonal Antibody, HRP Conjugated

A68804
  • EUR 754.26
  • EUR 293.70
  • EUR 470.80
  • 100 ?g
  • 50 ul
  • 100 ul

GNAS Polyclonal Antibody, HRP Conjugated

A64423
  • EUR 684.66
  • EUR 302.50
  • EUR 423.50
  • 100 µg
  • 50 ul
  • 100 ul

GNAS Polyclonal Antibody, FITC Conjugated

A68805
  • EUR 754.26
  • EUR 293.70
  • EUR 470.80
  • 100 ?g
  • 50 ul
  • 100 ul

GNAS Polyclonal Antibody, FITC Conjugated

A64424
  • EUR 684.66
  • EUR 302.50
  • EUR 423.50
  • 100 µg
  • 50 ul
  • 100 ul

ARP41764_T100 - GNAS antibody - N-terminal region (ARP41764_T100)

ARP41764_T100 100ul
EUR 339

ARP41765_T100 - GNAS antibody - C-terminal region (ARP41765_T100)

ARP41765_T100 100ul
EUR 339

ARP42693_P050 - GNAS antibody - N-terminal region (ARP42693_P050)

ARP42693_P050 100ul
EUR 389

ARP42694_T100 - GNAS antibody - N-terminal region (ARP42694_T100)

ARP42694_T100 100ul
EUR 339

GNAS Polyclonal Antibody, Biotin Conjugated

A68806
  • EUR 754.26
  • EUR 293.70
  • EUR 470.80
  • 100 ?g
  • 50 ul
  • 100 ul

GNAS Polyclonal Antibody, Biotin Conjugated

A64425
  • EUR 684.66
  • EUR 302.50
  • EUR 423.50
  • 100 µg
  • 50 ul
  • 100 ul

GNAS mouse monoclonal antibody,clone OTI7H4

TA809260 100 µl Ask for price

GNAS mouse monoclonal antibody,clone OTI7H4

TA809260S 30 µl Ask for price

GNAS mouse monoclonal antibody,clone OTI7A6

TA809270 100 µl Ask for price

GNAS mouse monoclonal antibody,clone OTI7A6

TA809270S 30 µl Ask for price

GNAS mouse monoclonal antibody,clone OTI7A4

TA809314 100 µl Ask for price

GNAS mouse monoclonal antibody,clone OTI7A4

TA809314S 30 µl Ask for price

GNAS mouse monoclonal antibody,clone OTI7D7

TA809326 100 µl Ask for price

GNAS mouse monoclonal antibody,clone OTI7D7

TA809326S 30 µl Ask for price

GNAS Rabbit Polyclonal (aa385-394) Antibody

TA317706 50 µg Ask for price

GNAS mouse monoclonal antibody,clone OTI13D7

TA809271 100 µl Ask for price

GNAS mouse monoclonal antibody,clone OTI13D7

TA809271S 30 µl Ask for price

GNAS mouse monoclonal antibody,clone OTI12D9

TA809313 100 µl Ask for price

GNAS mouse monoclonal antibody,clone OTI12D9

TA809313S 30 µl Ask for price

GNAS mouse monoclonal antibody,clone OTI13G5

TA809325 100 µl Ask for price

GNAS mouse monoclonal antibody,clone OTI13G5

TA809325S 30 µl Ask for price

GNAS mouse monoclonal antibody, clone N192/12

73-211 5 ml Ask for price

GNAS mouse monoclonal antibody, clone N192/12

75-211 100 µl Ask for price

Gnas/ Rat Gnas ELISA Kit

ELI-47242r 96 Tests
EUR 1063.2

Gnas/ Rat Gnas ELISA Kit

ELI-27931r 96 Tests
EUR 1063.2

Gnas/ Rat Gnas ELISA Kit

ELI-35065r 96 Tests
EUR 1063.2

Gnas/ Rat Gnas ELISA Kit

ELI-12714r 96 Tests
EUR 1063.2

Gnas (untagged) - Rat GNAS complex locus (Gnas), transcript variant 4

RN216170 10 µg Ask for price

Gnas (untagged) - Rat GNAS complex locus (Gnas), transcript variant 5

RN216171 10 µg Ask for price

GNAS (untagged)-Human GNAS complex locus (GNAS), transcript variant 3

SC127619 10 µg Ask for price

GNAS (untagged)-Human GNAS complex locus (GNAS), transcript variant 1

SC109275 10 µg Ask for price

GNAS (untagged)-Human GNAS complex locus (GNAS), transcript variant 4

SC109276 10 µg Ask for price

GNAS (untagged)-Human GNAS complex locus (GNAS), transcript variant 7

SC315542 10 µg Ask for price

GNAS (untagged)-Human GNAS complex locus (GNAS), transcript variant 6

SC315545 10 µg Ask for price

GNAS (untagged)-Human GNAS complex locus (GNAS), transcript variant 2

SC315599 10 µg Ask for price

GNAS (untagged)-Human GNAS complex locus (GNAS), transcript variant 2

SC318458 10 µg Ask for price

G protein alpha S (GNAS) rabbit polyclonal antibody

AP17431PU-N 400 µl Ask for price

GNAS (C-term) rabbit polyclonal antibody, Aff - Purified

AP51874PU-N 400 µl Ask for price

GNAS (GFP-tagged) - Human GNAS complex locus (GNAS), transcript variant 1

RG214197 10 µg Ask for price

GNAS (GFP-tagged) - Human GNAS complex locus (GNAS), transcript variant 2

RG214253 10 µg Ask for price

GNAS (GFP-tagged) - Human GNAS complex locus (GNAS), transcript variant 3

RG214318 10 µg Ask for price

GNAS (GFP-tagged) - Human GNAS complex locus (GNAS), transcript variant 4

RG212804 10 µg Ask for price

GNAS (GFP-tagged) - Human GNAS complex locus (GNAS), transcript variant 6

RG222992 10 µg Ask for price

GNAS (GFP-tagged) - Human GNAS complex locus (GNAS), transcript variant 7

RG216883 10 µg Ask for price

GNAS (GFP-tagged) - Human GNAS complex locus (GNAS), transcript variant 2

RG217421 10 µg Ask for price

G protein alpha S (GNAS) (164-394) rabbit polyclonal antibody, Aff - Purified

AP23581PU-N 50 µl Ask for price

Gnas (myc-DDK-tagged) - Rat GNAS complex locus (Gnas), transcript variant 4

RR216170 10 µg Ask for price

Gnas (myc-DDK-tagged) - Rat GNAS complex locus (Gnas), transcript variant 5

RR216171 10 µg Ask for price

GNAS (Myc-DDK-tagged)-Human GNAS complex locus (GNAS), transcript variant 2

RC214253 10 µg Ask for price

GNAS (Myc-DDK-tagged)-Human GNAS complex locus (GNAS), transcript variant 3

RC214318 10 µg Ask for price

GNAS (Myc-DDK-tagged)-Human GNAS complex locus (GNAS), transcript variant 1

RC214197 10 µg Ask for price

GNAS (Myc-DDK-tagged)-Human GNAS complex locus (GNAS), transcript variant 4

RC212804 10 µg Ask for price

GNAS (Myc-DDK-tagged)-Human GNAS complex locus (GNAS), transcript variant 7

RC216883 10 µg Ask for price

GNAS (Myc-DDK-tagged)-Human GNAS complex locus (GNAS), transcript variant 6

RC222992 10 µg Ask for price

GNAS (Myc-DDK-tagged)-Human GNAS complex locus (GNAS), transcript variant 2

RC217421 10 µg Ask for price

Gnas (untagged ORF) - Rat GNAS complex locus (Gnas), transcript variant 2, (10 ug)

RN200464 10 µg Ask for price

Gnas (untagged ORF) - Rat GNAS complex locus (Gnas), transcript variant 3, (10 ug)

RN200465 10 µg Ask for price

Gnas (untagged ORF) - Rat GNAS complex locus (Gnas), transcript variant 1, (10 ug)

RN200466 10 µg Ask for price

GNAS siRNA

20-abx918154
  • EUR 661.20
  • EUR 878.40
  • 15 nmol
  • 30 nmol

GNAS siRNA

20-abx918155
  • EUR 661.20
  • EUR 878.40
  • 15 nmol
  • 30 nmol

GNAS siRNA

20-abx918156
  • EUR 661.20
  • EUR 878.40
  • 15 nmol
  • 30 nmol

GNAS siRNA

20-abx918157
  • EUR 661.20
  • EUR 878.40
  • 15 nmol
  • 30 nmol

GNAS siRNA

20-abx918158
  • EUR 661.20
  • EUR 878.40
  • 15 nmol
  • 30 nmol

GNAS siRNA

20-abx918159
  • EUR 661.20
  • EUR 878.40
  • 15 nmol
  • 30 nmol

GNAS siRNA

20-abx918160
  • EUR 661.20
  • EUR 878.40
  • 15 nmol
  • 30 nmol

GNAS siRNA

20-abx918161
  • EUR 661.20
  • EUR 878.40
  • 15 nmol
  • 30 nmol

GNAS siRNA

20-abx900009
  • EUR 661.20
  • EUR 878.40
  • 15 nmol
  • 30 nmol

GNAS siRNA

20-abx900030
  • EUR 661.20
  • EUR 878.40
  • 15 nmol
  • 30 nmol

Guanine Nucleotide-Binding Protein G(s) Subunit Alpha Isoforms Short (GNAS) Antibody

abx233536-100ug 100 ug
EUR 577.2

Guanine Nucleotide-Binding Protein G(s) Subunit Alpha Isoforms Short (GNAS) Antibody

abx224154-100ug 100 ug
EUR 493.2

Guanine Nucleotide-Binding Protein G(s) Subunit Alpha Isoforms Short (GNAS) Antibody

20-abx141695
  • EUR 444.00
  • EUR 727.20
  • EUR 360.00
  • 100 ul
  • 200 ul
  • 50 ul

Guanine Nucleotide-Binding Protein G(s) Subunit Alpha Isoforms Short (GNAS) Antibody

abx146570-100ug 100 ug
EUR 526.8

Guanine Nucleotide-Binding Protein G(s) Subunit Alpha Isoforms Short (GNAS) Antibody

abx146571-100ug 100 ug
EUR 526.8

Guanine Nucleotide-Binding Protein G(s) Subunit Alpha Isoforms Short (GNAS) Antibody

abx025004-100ul 100 ul
EUR 627.6

Guanine Nucleotide-Binding Protein G(s) Subunit Alpha Isoforms Short (GNAS) Antibody

abx025024-400ul 400 ul
EUR 627.6

Guanine Nucleotide-Binding Protein G(s) Subunit Alpha Isoforms Short (GNAS) Antibody

abx025024-80l 80 µl
EUR 343.2

Guanine Nucleotide-Binding Protein G(s) Subunit Alpha Isoforms Short (GNAS) Antibody

abx030399-400ul 400 ul
EUR 627.6

Guanine Nucleotide-Binding Protein G(s) Subunit Alpha Isoforms Short (GNAS) Antibody

abx030399-80l 80 µl
EUR 343.2

Guanine Nucleotide-Binding Protein G(s) Subunit Alpha Isoforms Short (GNAS) Antibody

abx016141-100ug 100 ug
EUR 493.2

Guanine Nucleotide-Binding Protein G(s) Subunit Alpha Isoforms Short (GNAS) Antibody

abx033029-400ul 400 ul
EUR 627.6

Guanine Nucleotide-Binding Protein G(s) Subunit Alpha Isoforms Short (GNAS) Antibody

abx033029-80l 80 µl
EUR 343.2

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